Longevity Medicine
What Is NAD Therapy?
Last reviewed: May 2026 · Haute MD Editorial Team
NAD+ is a coenzyme essential for energy production, DNA repair, and activation of sirtuins linked to longevity. NAD+ levels decline approximately 50% between ages 40-60. Administration methods include IV infusion, subcutaneous injection, oral precursors (NMN, NR), and nasal spray.
Why NAD+ matters
NAD+ is required for mitochondrial energy production, DNA repair, sirtuin activation, and hundreds of metabolic reactions. Declining NAD+ levels are implicated in many hallmarks of aging including mitochondrial dysfunction and impaired DNA repair.
How NAD+ is administered
IV infusions (typically 500-1000 mg over 1-4 hours) deliver the highest doses. Subcutaneous injections and oral precursors (NMN, NR) provide more practical ongoing support.
Frequently Asked Questions
Is NAD+ therapy proven?
Animal studies and early human research are promising. Larger randomized human trials are ongoing. NMN and NR are well-tolerated and reliably raise NAD+ levels.
How often is NAD+ therapy administered?
Protocols vary. Initial IV protocols may be daily for a week followed by maintenance every 2-4 weeks. Oral precursors are taken daily.
Are there side effects?
IV NAD+ can cause chest pressure, nausea, or flushing during infusion if administered too quickly. Oral precursors are generally well-tolerated.
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Longevity Medicine · Miami Beach, FL
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Longevity Medicine · New York, NY
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Longevity Medicine · New York, NY
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