Weight Loss & Metabolic Health
What Is a Comprehensive Metabolic Evaluation?
Last reviewed: May 2026 · Haute MD Editorial Team
A comprehensive metabolic evaluation is a detailed assessment of how your body processes energy — including hormonal, inflammatory, nutritional, and cardiovascular markers. Typical components include fasting insulin, HbA1c, lipid panel (with particle size), thyroid panel, sex hormones, cortisol, vitamin D, B12, ferritin, inflammatory markers (hs-CRP), and often body composition.
Why it matters for weight loss
Standard labs often miss the metabolic dysfunction underlying weight resistance. Insulin resistance can be present years before diabetes shows on HbA1c. Low thyroid hormone, low testosterone, low vitamin D, and chronic inflammation all impair weight loss.
What's typically included
Comprehensive metabolic panel, fasting insulin, HbA1c, lipid panel (advanced if available), TSH/free T4/free T3, sex hormones, cortisol (AM or salivary), vitamin D, B12, ferritin, hs-CRP, homocysteine, uric acid, and body composition (DEXA preferred).
How to interpret results
Work with a physician trained in functional or obesity medicine. Reference ranges are population averages, not optimal. Many people benefit from interventions even when 'in range.'
Frequently Asked Questions
How much does this cost?
Insurance often covers most; cash-pay is typically $400-$1,200 depending on tests.
How often should I get a comprehensive panel?
Annually for healthy adults; every 3 to 6 months when actively managing weight or hormones.
Will my insurance cover advanced testing?
Basic panels yes; advanced lipid testing, cortisol, and inflammation markers sometimes.
Can I order these labs myself?
Yes — direct-to-consumer options (Quest, LabCorp, Function Health) are increasingly available.
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Dr. Alexander Golberg
Internal Medicine · New York, NY
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Dr. Kern Brar
MD
Internal Medicine · Oceanside, CA
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